Microfluidic system is the useful tool for automatically massive production, especially polymer based microspheres. Polymer based microspheres are synthesized through oil-water emulsion in microfluidic system under UV radiation. Laccases are multi-copper oxidases found in plants, fungi, and bacteria. Immobilized Laccase can effectively degrade and achieve 76.05% of degradation efficiency endocrine disruptor-Bisphenol A (BPA) in 10 minute.