One is a novel IOP reducing agent for glaucoma that is effective in reducing intraocular pressure (IOP) and preventing eye irritation. The drug works by relaxing the eye‘s trabecular meshwork (TM) and allowing the aqueous humor (AH) to flow out, thereby lowering the IOP. Another is a delivery system in eye drop form with a high drug solubility and superior delivery efficiency in posterior eye. It is used for the treatment of wet age-related macular degeneration (wet AMD).