High-quality Fc Receptor Proteins

 

Category: *CDMO

Exhibitor: ACROBIOSYSTEMS CO., LTD.

Booth No: M1033

 

Characteristic

 

The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half-life, while that between the Fc fragment and FcγRIIIa (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Therefore, candidates must be tested against a panel of receptors during antibody engineering.

ACROBiosystems offers a comprehensive collection of recombinant Fc receptor proteins, including their common variants, to expedite your antibody drug development.

Advantages of Fc receptor protein products
• Expressed by HEK293 Cells: post-translational modification and proper protein folding
• Multiple species: Human, Mouse, Cynomolgus/Rhesus macaque, Rat, Porcine, Rabbit, Feline, Bovine, can be fully applied to different cross species experiments
• High purity: SDS-PAGE verification purity>95%, SEC-MALS verification purity>90%
• Low endotoxin: ＜1.0 EU/µg
• High stability: strict quality control to ensure high batch-to-batch consistency
• Biotinylated Fc Receptor proteins labeled with AvitagTM offered: the labeling efficiency is high, and the labeling site is specific and clear, which is suitable for ELISA/SPR/BLI detection based on binding to streptavidin in the process of drug development and optimization process
• Affinity verified by SPR & BLI: activity guaranteed, and protocols offered free of charge.

 

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