Diagnostic Kits And Methods Configured To Rapidly And Non-Invasively Determine Physiologic Levels Of Galactose-Deficient IgA1 (GD-IgA1) In The Subjects Of IgA Nephropathy

Exhibitor: NATIONAL DEFENSE MEDICAL CENTER

Booth No: N/A

Characteristic

IgA nephropathy (IgAN), the most common cause of glomerulonephritis worldwide. Previous studies have shown that IgAN is closely related to the abnormality of O-glycosylation of galactose-deficiency in immunoglobulin A (Gd-IgA1). The diagnosis of IgAN is still characterized by clinical characterization and invasive surgery, and pathological interpretation of renal tissue sections is performed to confirm the lesion. We found that CGL has a higher binding capacity to Gd-IgA1 and ELISA based CGL binding assay to analysis serum levels of Gd-IgA1 expression were significantly increased in IgAN patients than healthy control. This patent, we claimed that a novel analytical method using lectin CGL which specifically GalNAc/ Gal.