🌐 NanoLuc® Luciferase: A Small but Mighty Bioluminescent Tool

Category: Cell Therapy and Regenerative Medicine

Exhibitor: GENELABS LIFE SCIENCE CORPORATION

Booth No: M929

Characteristic

🔬 Product Features
Ultra-High Brightness: NanoLuc® is a small (19.1kDa), highly stable enzyme that uses the novel substrate furimazine to produce luminescence approximately 100 times brighter than traditional luciferases.

ATP Independence: Its luminescent reaction is ATP-independent, reducing background signals and enhancing sensitivity.

Ideal for Fusion Proteins: Its small size makes it an excellent fusion partner for studying protein dynamics in live cells.

🧪 Applications
1. Gene Expression Reporting
Endogenous Promoter Activity Measurement: By integrating NanoLuc® into endogenous loci using CRISPR-Cas9, precise monitoring of promoter activity is achieved.

2. Protein-Protein Interaction Analysis
NanoBiT® Technology: NanoLuc® is split into two subunits (LgBiT and SmBiT), each fused to target proteins. Interaction of these proteins brings the subunits together, emitting a luminescent signal, enabling real-time monitoring of protein interactions in live cells.

3. In Vivo Imaging
Nano-Glo® FFz Substrate: Specifically designed for in vivo imaging, this substrate enhances solubility and bioavailability, suitable for tracking viral distribution, CAR T-cell localization, and more.

🛠️ Related Products
Nano-Glo® Luciferase Assay System: A single-addition reagent suitable for highly sensitive NanoLuc® detection.

Nano-Glo® Dual-Luciferase® Reporter Assay System: Simultaneously detects NanoLuc® and firefly luciferase, ideal for dual-reporter gene experiments.

Nano-Glo® Fluorofurimazine In Vivo Substrate (FFz): An optimized substrate for in vivo imaging, enhancing signal stability and brightness.