🌐 Kinase Screening Tailored Services｜Smarter Profiling, Real Results

Exhibitor: GENELABS LIFE SCIENCE CORPORATION

Booth No: M929

Characteristic

🔍 Compare Cell-Free vs. Live-Cell Profiling

Method- Cell-Free
🔬 Environment- Enzyme-based, no cells
🎯 Target Info- Initial binding info
⚠️ Limitation- High false positives
🧪 Application- Early compound screening
✅ Accuracy- Less predictive

Method- Live-Cell
🔬 Environment- Real cellular context
🎯 Target Info- True in-cell occupancy
⚠️ Limitation- Influenced by cellular pathways
🧪 Application- Lead confirmation & optimization
✅ Accuracy- Better in vivo correlation

💡 Why Live-Cell Profiling is Recommended
1. “Target engagement (TE) in live cells offers direct evidence of compound-target interaction inside real biological systems.”
2. Based on NanoBRET® using NanoLuc® tags and fluorescent tracers
3. Detects off-targets missed in cell-free systems
4. Reveals selectivity in real time – e.g., RIPK2 and NTRK2 with sorafenib

⚠️ TE data revealed the cytotoxic effect was due to microtubule disruption, not MET inhibition – highlighting the risk of ignoring TE.

🔬 Kinase Profiling Powered by NanoBRET® TE
🔬 192 or 300-kinase panels available
🧬 100+ disease mutants for comparison
📊 Single-point or dose-response screening
⏱️ Fast turnaround: 2–3 weeks
🛠️ Bespoke panels available on request

🚀 Choose a Path Closer to the Truth
📩 Contact Genelabs (勁因科技) for your tailored kinase screening solution today
🔗 Explore the service- https://reurl.cc/1Kqy2V