NTHU team achieves breakthrough in breast cancer chemoresistant targeted therapy
Exhibitor: LILY WANG LAB NTHU
Date: 2025-06-18
Booth No.: N915
A research team led by Professor Lily Hui-Ching Wang at National Tsing Hua University has developed KIF2Ci, the world’s first-in-class small-molecule inhibitor targeting KIF2C, a kinesin-13 protein involved in microtubule depolymerization and mitosis. Published in Developmental Cell, the study reveals that KIF2Ci shows strong antitumor effects in triple-negative breast cancer (TNBC), especially when combined with Paclitaxel.
KIF2Ci induces mitotic arrest and apoptosis in paclitaxel-resistant cells and demonstrates synthetic lethality with over 50% of current chemotherapies, significantly enhancing treatment efficacy and overcoming chemoresistance. The team is currently conducting preclinical validation to advance KIF2Ci toward clinical trials. The compound holds promise as a dual-action agent—tumor suppression and chemosensitization—and may be applicable across a range of solid and drug-resistant tumors. With its broad-spectrum potential, KIF2Ci could support combination regimens in diverse solid tumors and resistant cancers, positioning it as a high-value asset in oncology drug development.
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