EXONOX BIOSCIENCES, INC.

 

Area: Government, Academia and Research Institutes

Booth No: M134

Website: https://exonoxbio.com/

 

Exhibitor Profile

 

RAB8A-Mediated Exosomal Cargo Redistribution as a Pre-Metastatic Signature for Patient Stratification in Triple-Negative Breast Cancer
Plasma exosomes carry proteomic cargo that reflects tumor biology prior to overt metastasis. We profiled peripheral blood plasma exosomes from 49 TNBC patients (metastatic/recurrent n=11, stable n=38) using LC-MS/MS proteomics across 17 sample groups.
RAB8A, a vesicular trafficking GTPase, coordinates bidirectional cargo redistribution in tumor-derived exosomes. This generates two co-occurring signatures: CLP- 67 cytoskeletal, quality-control, and platelet-adhesion proteins depleted in metastatic exosomes (FC≤0.75, p<0.05); and MCEP- 10 immune/metabolic proteins enriched (FC≥1.33, p<0.05), including complement activators, myeloid markers, and metabolic effectors.
We derived MCRS (Metastatic Cargo Redistribution Score) = mean(log₂[MCEP₁₀]) − mean(log₂[CLP₆₇]). MCRS>0 is classified CR+ (pre-metastatic activation). RAB8A knockdown selectively suppressed migration in MDA-MB-231 and MDA-MB-468 cell lines (NHRI-commissioned assay, p<0.05).

 

Exhibit Products

 

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  RAB8A-Mediated Exosomal Cargo Redistribution as a Pre-Metastatic Signature for Patient Stratification in Triple-Negative Breast Cancer

 

 

 

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