Developing novel therapeutics for Alzheimer’s disease and neurodegenerative disorders
Exhibitor: NEURAL REJUVENATION TEAM, ACADEMIA SINICA
Date: 2025-06-18
Booth No.: N915
Alzheimer's Disease (AD) is the most common neurodegenerative disorder in aging societies, affecting millions of people worldwide. With the aging population, the number of patients is continually increasing, posing a growing healthcare challenge. Current clinical medications only provide symptomatic relief with limited efficacy and cannot significantly alter the progression of the disease. Therefore, finding new therapeutic approaches has become a major research focus. The pathogenesis of AD is complicated, in which brain energy deficit is a key factor contributing the occurrence of AD. J4, an equilibrative nucleoside transporter 1 (ENT1) inhibitor, offers a novel mechanism to normalize energy imbalance in the brain and treat neuronal energy deficits. Non-clinical experiments have demonstrated remarkable therapeutic effects of J4 in different AD mouse models, improving cognitive impairments and spatial memory deficits, reducing abnormal accumulation of Aβ and tau proteins, alleviating oxidative stress and neuroinflammation, and enhancing mitochondrial and glucose metabolism activity. J4 has shown superior efficacy compared to conventional treatments like donepezil and memantine. The research team has completed non-clinical pharmacokinetics, pharmacodynamics, and safety assessments of J4, and successfully obtained Investigational New Drug (IND) approvals from both the U.S. FDA and Taiwan FDA in 2024. The compound is currently undergoing a Phase I clinical trial in Taiwan. J4, an oral small-molecule drug with a novel mechanism of action, offers ease of administration and cost-effectiveness. Its strong efficacy and favorable safety profile provide significant potential for further development. J4 has been granted patents in multiple countries. The team plans to spin off into a startup company and collaborate with domestic and international pharmaceutical companies and research institutions to accelerate clinical development through resource raising or patent licensing. The development of J4 aims to provide Alzheimer’s disease patients with more treatment options, improve disease outcomes and quality of life, and reduce the long-term caregiving burden and healthcare costs for families. |
More Exhibitor's Press Release
- Link-Best debuted at BIO Asia Exhibition. Products attracted attention and Ignited Spark. LINK-BEST BIOSCIENCE CO., LTD. / 2025-08-20
- IOT無線連續監測系統 - 廠房、倉儲、實驗室 溫、濕度測繪 XIN TOP CORPORATION / 2025-08-20
- GoldenBiotech-Advancing First-line treatment of Meta. PanCa GOLDEN BIOTECHNOLOGY CORP. / 2025-08-10
- GlobalBio: 國鼎生技-開發Antroquinonol 造福抗癌研究治療 GOLDEN BIOTECHNOLOGY CORP. / 2025-08-10
- 現場校正、抽檢應用 攜帶式測量儀 XIN TOP CORPORATION / 2025-08-07
- Honya Medical Strengthens Local Presence and Expands Toward Global Clinical Excellence HONYA MEDICAL CO., LTD. / 2025-07-30
- Honya’s MiSaver: A New Frontier in Treating Heart Damage After Heart Attacks HONYA MEDICAL CO., LTD. / 2025-07-30
- AAVnerGene and TFBS Bioscience Announce Collaboration to Develop Innovative AAV Technology Platform TFBS BIOSCIENCE, INC. / 2025-07-25
- Visit Us at BIO Asia–Taiwan 2025! July 24 – July 27 GENERAL BIOLOGICALS CORPORATION (GBC) / 2025-07-25
- GBC CellBio™ a2000 has been recognized with a 2025 Edison Award. GENERAL BIOLOGICALS CORPORATION (GBC) / 2025-07-24
- GBC AI Biotech Building Officially Commissioned. GENERAL BIOLOGICALS CORPORATION (GBC) / 2025-07-24
- Your Invitation to Innovation – Booth M412 Forum MAJOR SCIENCE CO.,LTD / 2025-07-24
- Ecotek Engineering Corp.: Your Integrated Partner for Biopharma Facility and Process Equipment Solut MAJOR SCIENCE CO.,LTD / 2025-07-24
- About major science - Create life sciences research instruments through quality and innovation MAJOR SCIENCE CO.,LTD / 2025-07-24
- MarkerX Unveils MyeloTrak™ at BIO Asia, Redefining Multiple Myeloma Management with Non-invasive, Pr MARKER X CO., LTD. / 2025-07-23
- CancerFree Biotech Selected for OIST Startup Accelerator Program CANCERFREE BIOTECH LTD. / 2025-07-23
- AI Sparks a New Wave in Cancer Research: How a Taiwanese Startup Is Breaking Lab Bottlenecks and Ad CANCERFREE BIOTECH LTD. / 2025-07-23
- Transin Biomedical showcases the innovative strength of smart medical devices TRANSIN BIOMEDICAL CO., LTD. / 2025-07-23
- TaiMed Biologics Hosts Interactive Activities at BIO Asia 2025 to Promote HIV Awareness TAIMED BIOLOGICS INC. / 2025-07-22
- A Pioneer for Over Two Decades, Cell-Bio Biotechnology to Showcase Comprehensive Solutions at BioAsi CELL-BIO BIOTECHNOLOGY CO., LTD. / 2025-07-22