Antroquinonol for Acute Myeloid Leukemia (AML)

Model: Antroquinonol for Acute Myeloid Leukemia (AML)

Booth No: L218

Characteristic

Golden Biotech's lead compound, Antroquinonol, is a novel small molecule targeting key oncogenic and immunological pathways, currently in development for multiple oncology indications. In metastatic pancreatic cancer, Antroquinonol—administered orally—has shown compelling results when combined with the standard of care (nab-paclitaxel plus gemcitabine). Antroquinonol’s excellent safety profile is distinguished by a significant reduction in hematologic adverse events-such as neutropenia, thrombocytopenia, anemia, and leukopenia-compared to standard treatments, as well as lower rates of non-hematologic side effects like fatigue and neuropathy. Its oral formulation, low potential for drug-drug interactions, and robust safety data make it an attractive candidate for both combination and standalone use.
Mechanistically, Antroquinonol inhibits the PI3K/Akt/mTOR pathway and disrupts cell cycle progression, inducing apoptosis, autophagy, and senescence in pancreatic cancer cells-particularly relevant for the high prevalence of KRAS mutations in this disease. The compound has received Orphan Drug Designation from the FDA for pancreatic cancer, AML, and hepatocellular carcinoma, and EMA for pancreatic cancer, underscoring its therapeutic promise.
Golden Biotech presents Antroquinonol, a novel small molecule, which exhibits significant anti-cancer activities through selected mechanisms targeting cancer cell growth, survival and metastasis. Antroquinonol has completed Phase 2 clinical studies in Metastatic Pancreatic cancer, Non-small Cell Lung cancer and Acute Myeloid Leukemia.

We aim to explore strategic collaborations in clinical development, licensing, and global commercialization.