ESCO - BelloCell™ High-Density Cell Culture System

Model: BelloStage™ 3000/7000

Category: Cell Therapy and Regenerative Medicine

Booth No: M1231

Characteristic

BelloStage™ 3000/7000 × BelloCell™ High-Density Cell Culture System
High-Efficiency Cell Expansion × Dynamic Automated Bioprocess Platform

The BelloStage™ 3000/7000 integrated with the BelloCell™ high-density culture system provides an automated dynamic cell culture solution designed to operate inside a standard CO₂ incubator, enabling scalable and reproducible high-yield cell production.

Based on the proprietary “Tide Motion” culture principle, the system precisely controls medium level fluctuations and gas exchange cycles, allowing cells to alternate between submerged and aerated conditions. This dynamic environment significantly enhances oxygen transfer and nutrient exchange while minimizing shear stress, overcoming key limitations of conventional static or roller-bottle systems.

BelloStage™ 3000 supports stable intermittent operation for multiple BelloCell vessels simultaneously, while BelloStage™ 7000 enables continuous perfusion culture when combined with an external feeding system (BelloFeeder), making it suitable for long-term and process-intensive production workflows.

The BelloCell™ culture bottle utilizes BioNOC II high-surface-area porous carriers, providing an extensive attachment surface that supports ultra-high cell density growth up to 10⁹ cells per bottle. It is widely applied in recombinant protein production, antibody manufacturing, viral vector preparation, and advanced cell-based research.

Key Features
👍Ultra-high density cell culture (up to 10⁹ cells/bottle)
👍Tide Motion dynamic culture for enhanced oxygenation and nutrient exchange
👍Low shear stress environment for improved cell viability
👍Reduced culture medium consumption, lowering overall production cost
👍Compatible with standard CO₂ incubators
👍Supports both batch and continuous operation modes
👍Pre-sterilized, ready-to-use system for easy operation

Applications
Protein & antibody production | Viral vector manufacturing | Cell therapy research | Drug discovery | Adherent and suspension cell expansion