Inside Therapeutics ─ TAMARA LNP formulation system

Booth No: M724

Characteristic

TAMARA Nanoparticle Preparation System is an innovative microfluidic technology platform designed for research applications. The system supports the development of various formulations, including LNPs, liposomes, PLGA nanoparticles, and SLNs, providing a complete workflow solution from early-stage screening to animal studies within a single platform.
Core Advantages

◆ Precise Particle Size Control
By adjusting the Total Flow Rate (TFR) and Flow Rate Ratio (FRR), nanoparticle size can be precisely controlled within a range of 50–200 nm, with batch-to-batch reproducibility better than ±3%.
◆ High Encapsulation Efficiency
The microfluidic formulation approach achieves RNA encapsulation efficiencies (EE) of up to 98%, while maintaining a Polydispersity Index (PDI) typically below 0.2, significantly outperforming conventional batch preparation methods.
◆ Plug-and-Play Operation
The touchscreen interface enables simple and intuitive operation. After setting the formulation parameters, users only need to load the reagents, attach the module, and start the run. Each preparation can be completed in less than 2 minutes.
◆ Reusable Chip Design
A single chip integrates both Herringbone and Baffle mixer designs. Users can switch between mixers simply by changing the chip orientation. The chip can be cleaned and reused multiple times, minimizing consumable costs.

Microfluidic Formulation Principle -
TAMARA utilizes a nanoprecipitation-based encapsulation mechanism. Organic solvents containing lipids or polymers are rapidly and uniformly mixed with aqueous reagents within microchannels, causing a sudden reduction in lipid solubility and spontaneous self-assembly into nanoparticles.

Product Benefits
✓ One platform for the preparation of all nanoparticle types
✓ Optimized particle size, PDI, encapsulation efficiency, and reproducibility
✓ Complete workflow support from formulation screening to in vivo studies
✓ Maximized reagent utilization efficiency
✓ Accelerated laboratory workflow
✓ Minimized cost per preparation