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Lesion-selective Alb-CTLA-4Ig is safe and effective in treating chronic inflammation

Category: Pharmaceutical

Exhibitor: NATIONAL YANG MING CHIAO TUNG UNIVERSITY

Booth No: N327A

Characteristic

CTLA-4Ig has been approved for the treatment of rheumatoid arthritis but may cause systemic immunosuppression. To improve safety, we designed Alb-CTLA-4Ig, a novel recombinant protein linked to albumin that can be cleaved by proteolytic enzyme. Alb-CTLA-4Ig remains inactive in normal tissues but can be cleaved by MMPs at sites of inflammation. Proteolytic enzyme-cleaved Alb-CTLA-4Ig exhibits potent binding and T cell inhibition. In mice model with arthritis, it reduced joint inflammation while preserving antimicrobial immunity. Alb-CTLA-4Ig provides safer therapy for inflammatory diseases.

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