ADC Linkers and Dendrimers

 

Model: F1223, F1114, A3348, M3224 (Val-Cit-PAB 系列可切斷連接子)

Category: *CDMO

Exhibitor: KM3 SCIENTIFIC CORPORATION

Booth No: M206

 

Characteristic

 

TCI provides essential building blocks—from milligram-scale R&D to GMP ton-scale production—for the development of Next-Generation Drug Delivery Systems (DDS) and Antibody-Drug Conjugates (ADCs):
Enzymatically Cleavable Linkers: Offers dipeptide linkers such as Val-Cit-PAB. These linkers maintain high stability in blood circulation and are precisely cleaved by Cathepsin B upon entering tumor cell lysosomes, allowing for rapid payload release.
PEGylation Reagents: Supplies mono-/bi-functional PEGs and PEG oligomers with diverse chain lengths and terminal reactive groups. They impart "stealth" properties to drugs or nanocarriers, effectively preventing serum protein adsorption and significantly prolonging in vivo circulation half-life.
High-Purity Cross-Linkers: Consistently supplies various heterobifunctional cross-linkers like SMCC, GMBS, and SPDP, along with cutting-edge modifying molecules for copper-free click chemistry.
Dendrimer Building Blocks: Provides core monomers for synthesizing highly symmetric nanoscale macromolecules. Their hydrophobic internal cavities perfectly encapsulate poorly soluble drugs to achieve "zero-order controlled release," while their abundant hydrophilic surface groups can be conjugated with ligands for precise targeted drug delivery.

 

Other Products

 

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  Chemical intermediates/Customized synthesis

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  TCI Reagents

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  CUBIC Reagents for Animal Tissue, Whole-Organ and Whole-Body Clearing

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  Antifouling Zwitterionic Monomers

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  Presome® Lipid Blends and LNP Delivery Technology

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  Fuji Silysia (ARG / NH-SG Silica) ARG Silica：Arginine Silica NH-SG Silica：Neutral Sugar Grade Silica/ Sugar Grade Amino Silica

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  Extracellular Vesicle (EV) Surface Glycans and Related Reagents

 

 

 

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