Fluidity One-M

 

Model: Fluidity One-M

Category: Pharmaceutical

Exhibitor: COLD SPRING BIOTECH CORP.

Booth No: L118

 

Characteristic

 

Explore Protein Interactions with Precision and Efficiency
Understanding proteins and their interactions is critical in exploring the mechanisms of life and developing innovative therapies. Powered by advanced Microfluidic Diffusional Sizing (MDS) technology, Fluidity One M offers a comprehensive solution for protein and interaction analysis. From fundamental research to drug discovery, Fluidity One M helps you gain deeper insights into protein function and accelerates your development process.
Key Features of Fluidity One M:
1. Innovative In-Solution Measurement Technology
Built on Microfluidic Diffusional Sizing (MDS), Fluidity One M utilizes a unique in-solution approach to directly measure molecular size (Rh), binding affinity (KD), concentration, and binding stoichiometry. It eliminates the need for immobilization, allowing interactions to be measured in their native state for greater accuracy. Using fluorescence detection, MDS enables high-specificity binding analysis in complex biological samples such as serum and cell lysate.
2. Direct Measurement from Crude Samples – No Purification Needed
Fluidity One M enables direct analysis of crude biological samples such as serum, plasma, or cell lysate—eliminating time-consuming purification steps. It is compatible with a wide range of targets, from conventional proteins to challenging molecules like aggregates, membrane proteins, intrinsically disordered proteins, and PROTACs. Only 4 µL of sample is needed per data point, ensuring minimal sample consumption. The system also supports a variety of aqueous and biological buffers, including TRIS, HEPES, PBS, NaCl, KCl, TWEEN, DMSO, and DMF, offering high flexibility across experimental conditions.
3. Fast and Intuitive Workflow
With its mix-and-measure design, Fluidity One M is easy to learn—no special training required, and you can begin within a single day. It delivers 24 data points in just 25 minutes, quickly generating full binding curves and KD values to accelerate your research. The instrument features a fluidic-free design for minimal maintenance and uses single-use chip-plates to eliminate cross-contamination. From sample prep to data output, the entire process is fast, seamless, and efficient.
4. Comprehensive Multi-Attribute Analysis
Fluidity One M goes beyond measuring binding affinity. It simultaneously provides molecular size (Rh), calibration-free concentration, and binding stoichiometry—giving you a complete and assumption-free picture of protein interactions. This enables clear differentiation between high-affinity/low-concentration and low-affinity/high-concentration systems. The data can support morphological or structural studies and complement functional analyses. Rh can be measured across a range of 1–20 nm, suitable for peptides, multiprotein complexes, and fibrillar aggregates. It supports molecular weights from 1.4 kDa to 14 MDa and KD values ranging from pM to µM, covering both strong and weak interactions.

 

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